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A vaccine without a needle? U of M research suggests it may be in the future

Updated: 9:49 PM CDT May 27, 2021 In the field of biomedical engineering, University of Minnesota associate professor Dr. Chun Wang describes two unique challenges with vaccine delivery. The first challenge is obvious. “Needles and syringes,” Wang said. “It hurts!” The second challenge is less obvious, but just as important. Most vaccines must be preserved at low temperatures through the “cold chain,” which adds logistical difficulties and can sometimes disrupt access for rural or less accessible parts of the world. So, Dr. Wang and his colleagues at the U of M, along with other partner institutions, asked a simple question: What if you could deliver a vaccine without needing a refrigerator or a needle?

Therapeutics that can shut down harmful genes need a reliable delivery system

 E-Mail IMAGE: Aaliyah Shodeinde, a fourth-year graduate researcher in the McKetta Department of Chemical Engineering working in professor and drug delivery pioneer Nicholas Peppas lab. view more  Credit: The University of Texas at Austin Viruses attack the body by sending their genetic code DNA and RNA into cells and multiplying. A promising class of therapeutics that uses synthetic nucleic acids to target and shut down specific, harmful genes and prevent viruses from spreading is gaining steam. However, only a handful of siRNA, or other RNA interference-based therapeutics have been approved. One of the main problems is getting the siRNA into the body and guiding it to the target.

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