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A test which uses artificial intelligence (AI) to measure proteins present in some patients with advanced bowel cancer could hold the key to more targeted treatment, according to research published today.
A team at the University of Leeds collaborated with researchers at Roche Diagnostics to develop the technique, which will help doctors and patients to decide on the best treatment options.
They used samples from a previous trial funded by Cancer Research UK to look at the levels of two proteins, known as AREG and EREG, which are produced by some colorectal cancers.
Algorithms driven by AI enabled the researchers to show that patients with higher levels of these proteins received significant benefit from a treatment which inhibits a different protein involved in cancer cell growth, known as EGFR. Of equal importance, patients with low levels of the proteins did not benefit from the treatment.
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IMAGE: West Mato Volcano erupting in 2009. Image courtesy of the National Oceanic and Atmospheric Administration view more
Credit: Image courtesy of the National Oceanic and Atmospheric Administration
Volcanic eruptions deep in our oceans are capable of extremely powerful releases of energy, at a rate high enough to power the whole of the United States, according to research published today.
Eruptions from deep-sea volcanoes were long-thought to be relatively uninteresting compared with those on land. While terrestrial volcanoes often produce spectacular eruptions, dispersing volcanic ash into the environment, it was thought that deep marine eruptions only produced slow moving lava flows.
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The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus.
Researchers from the Wellcome Sanger Institute, Newcastle University, University College London, University of Cambridge, EMBL s European Bioinformatics Institute (EMBL-EBI) and their collaborators within the Human Cell Atlas initiative, found raised levels of specific immune cells in asymptomatic people. They also showed people with more serious symptoms had lost these protective cell types, but gained inflammatory cells. These differences in the immune response could help explain serious lung inflammation and blood clotting symptoms, and could be used to identify potential targets for developing therapies.
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Anglia Ruskin also among best in England for local growth and regeneration
Anglia Ruskin University (ARU) is in the top 10% of English higher education institutions (HEIs) for skills, enterprise and entrepreneurship and in the top 20% for local growth and regeneration, according to a new report by Research England.
The inaugural Knowledge Exchange Framework (KEF) has been developed to assess the interaction of England’s HEIs with business and the public, through seven key indicators. It sits alongside the Research Excellence Framework (REF) and the Teaching Excellence Framework (TEF) as England’s third pillar of university assessment.
ARU’s results demonstrate its significant contribution to economic, social and cultural wellbeing in the Eastern region and across the UK. A Government report published last year confirmed that ARU provides more graduates for the region than any other university.