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Scientists to present new findings on protein biochemistry, glycobiology at Life Science Symposium 2021

Scientists to present new findings on protein biochemistry, glycobiology at Life Science Symposium 2021
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Baden wübergThomas dyer seeleyMathias heikenwEmily hendersonLudger johannesTechnische universitaet braunschweigMiguel vencesChristian fankhauserMelina schuhAsifa akhtarStefan raunserInstitut curieRohini kunerMax planck institute for developmental biologyCornell university united statesUniversity of lausanne switzerland

Alterations in the 3D genome structure and effects on fertility revealed

Credit: Covadonga Vara and Aurora Ruiz-Herrera, UAB. The genome is tightly organised (packaged) within the cell nuclei. This three-dimensional (3D) genome organisation is fundamental, given that it regulates gene expression. A study led by scientists at the Universitat Autònoma de Barcelona (UAB) now demonstrates using mice models that the 3D organisation of the genome is extremely dynamic during the formation of male germ cells (precursors of spermatozoa) and that alterations in this structure can affect fertility. The research, published in Nature Communications, describes the 3D genome organisation in germ cells of wild populations of house mice (Mus musculus domesticus) with chromosomal rearrangements, alterations in the genome which change the structure of chromosomes. The study represents a significant advance in research into mechanisms generating and regulating the structure and function of the genome during the formation of gametes (oocytes and sperm).

Comunidad autonoma de catalunaCovadonga varaAurora ruiz herreraNature communicationsDepartment of cellular biologyNational centre for genomic analysisCentre for genomic regulationInstitute of biotechnologyCornell university united statesDepartment of animal biologyUniversitat autAssociated professorCellular biologyAnimal biologyPlant biologyNational centre

Alterations in 3D genome structure and effects on fertility revealed

Alterations in 3D genome structure and effects on fertility revealed
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Comunidad autonoma de catalunaCovadonga varaCristina marAurora ruiz herreraNature communicationsDepartment of cellular biologyNational centre for genomic analysisCentre for genomic regulationInstitute of biotechnologyCornell university united statesDepartment of animal biologyAnimal genomeLaia marUniversitat autAssociated professorCellular biology

How the fly selects its reproductive male - Communiqués de presse

How the fly selects its reproductive male Researchers from UNIGE have discovered a very small protein in Drosophila that plays a key role in how females select the semen that will fertilize its eggs when it mates with several males. Drosophila accessory glands consisting of two cell types (green “secondary cells” surrounded by red nuclei of the “main cells”). © Robert Maeda Even a well-characterized genome, such as that of the Drosophila the so-called fruit fly, still holds surprises. A team from the University of Geneva (UNIGE), Switzerland, in collaboration with Cornell University (USA) and the University of Groningen (Netherlands), has discovered an RNA coding for a micro-peptide – a very small protein – that plays a crucial role in the competition between spermatozoa from different males with which the female mates. In addition to shedding new light on this biological mechanism, this work, to be read in the journal

Robert maedaUniversity of groningen netherlandsProceedings of the national academy sciencesUniversity of genevaCornell university united statesDepartment of geneticsCornell universityUnited statesNational academyராபர்ட் மாயீடபல்கலைக்கழகம் ஆஃப் க்ராநிகந் நெதர்லாந்துபல்கலைக்கழகம் ஆஃப் ஜிநீவகார்னெல் பல்கலைக்கழகம் ஒன்றுபட்டது மாநிலங்களில்துறை ஆஃப் ஜெநெடிக்ஸ்கார்னெல் பல்கலைக்கழகம்ஒன்றுபட்டது மாநிலங்களில்

How the fly selects its reproductive male | EurekAlert! Science News

E-Mail IMAGE: Drosophila accessory glands consisting of two cell types (green secondary cells surrounded by red nuclei of the main cells ). view more Credit: © Robert Maeda Even a well-characterized genome, such as that of the Drosophila the so-called fruit fly, still holds surprises. A team from the University of Geneva (UNIGE), Switzerland, in collaboration with Cornell University (USA) and the University of Groningen (Netherlands), has discovered an RNA coding for a micro-peptide - a very small protein - that plays a crucial role in the competition between spermatozoa from different males with which the female mates. In addition to shedding new light on this biological mechanism, this work, to be read in the journal

Robert maedaUniversity of groningen netherlandsProceedings of the national academy sciencesUniversity of genevaCornell university united statesDepartment of geneticsCornell universityUnited statesNational academyராபர்ட் மாயீடபல்கலைக்கழகம் ஆஃப் க்ராநிகந் நெதர்லாந்துபல்கலைக்கழகம் ஆஃப் ஜிநீவகார்னெல் பல்கலைக்கழகம் ஒன்றுபட்டது மாநிலங்களில்துறை ஆஃப் ஜெநெடிக்ஸ்கார்னெல் பல்கலைக்கழகம்ஒன்றுபட்டது மாநிலங்களில்