Date Time
Pitt Awarded $10.7M for Alzheimer’s Disease Genetic Research
Despite decades of research and investment, the genetic underpinnings of Alzheimer’s disease are still largely unknown, stymieing drug development and early diagnosis efforts. A new $10.7 million, five-year project led by the University of Pittsburgh Graduate School of Public Health and Washington University School of Medicine in St. Louis aims to change that with the first comprehensive study using whole genome sequencing to address a critical gap in knowledge about the disease.
With funding from the National Institute on Aging, the research team plans to identify the genetic variants, genes and pathways that lead to formation of plaques and tangles, two specific biomarkers that begin accumulating in the brains of people with Alzheimer’s 15 to 25 years before they show symptoms.
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IMAGE: Professor of human genetics and epidemiology, University of Pittsburgh Graduate School of Public Health. view more
Credit: University of Pittsburgh
PITTSBURGH, May 5, 2021 - Despite decades of research and investment, the genetic underpinnings of Alzheimer s disease are still largely unknown, stymieing drug development and early diagnosis efforts. A new $10.7 million, five-year project led by the University of Pittsburgh Graduate School of Public Health and Washington University School of Medicine in St. Louis aims to change that with the first comprehensive study using whole genome sequencing to address a critical gap in knowledge about the disease.
With funding from the National Institute on Aging, the research team plans to identify the genetic variants, genes and pathways that lead to formation of plaques and tangles, two specific biomarkers that begin accumulating in the brains of people with Alzheimer s 15 to 25 years before they show symptoms.
During the 100 days that a pollution control system at Clairton Coke Works was offline following a 2018 fire, people living near the facility experienced worsened asthma symptoms, a study shows. Researchers at the University of Pittsburgh will publish their findings in an upcoming issue of the Journal of Allergy
Date Time
Asthma Exacerbations Followed Christmas Eve Coke Works Fire
Asthma exacerbations rose following a catastrophic Christmas Eve fire two years ago that destroyed pollution controls at the Clairton Coke Works the largest such facility in the nation, a University of Pittsburgh Graduate School of Public Health analysis concludes.
“In addition to verifying that people living within a 10-mile radius of the coke works had higher rates of asthma exacerbations and use of albuterol rescue medication than those living outside the radius, we learned that nearly half of the people with asthma closest to the fire were unaware of the pollution problem and, therefore, unable to take steps to avoid exposure,” said lead author Brandy Byrwa-Hill, M.S., a Ph.D. student in Pitt Public Health’s Department of Environmental and Occupational Health.
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