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Pediatric cardiac catheterization could be performed with low levels of radiation exposure using one center s as low as reasonably achievable (ALARA) protocol, researchers reported.
The strategy employed by Lisa Goto, MD, and colleagues at the Children s Hospital at Montefiore in New York City, resulted in favorable radiation levels across 95 catheterizations in 77 children weighing 20-40 kg (approximately 44-88 lbs):
Median fluoroscopy time: 11.9 minutes
Total air Kerma product: 38 mGy
Dose air product (DAP): 175 µGym
2
2/kg
Based on these findings, radiation exposure during cardiac catheterization with ALARA seems to compare favorably against published values, as Goto cited prior reports of air Kerma reaching 370-400 mGy and DAPs exceeding 2,000 µGym
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Scientists from several hospitals and research centers have shown what happens in individual cells of patients who died of COVID-19. In a study published in
Nature, the researchers describe how infected cells from multiple organs exhibited a range of molecular and genomic changes. They also saw signs of multiple, unsuccessful attempts by the lungs to repair themselves in response to respiratory failure, which is the leading cause of death in COVID-19 patients. You really feel the tragedy of the disease when you see that result, said Aviv Regev, co-senior author of the study and a core institute member at the Broad Institute of MIT and Harvard when the study began. The lung tries everything at its disposal, and it still can t fix itself. This was a very emotional study. We are grateful to the patients and families who agreed to donate tissue for COVID-19 research to help advance understanding of this devastating disease.
As of April 2021, yet another worldwide wave of SARS-CoV-2 infections is threatening to bring new daily highs in the mortality associated with the COVID-19 pand
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NEW YORK, NY (April 29, 2021) A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases.
Led by researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, the study found that in patients who died of the infection, COVID-19 unleashed a detrimental trifecta of runaway inflammation, direct destruction and impaired regeneration of lung cells involved in gas exchange, and accelerated lung scarring.
Though the study looked at lungs from patients who had died of the disease, it provides solid leads as to why survivors of severe COVID may experience long-term respiratory complications due to lung scarring.
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