Date Time
SARS-CoV-2 Research: Second possible effective mechanism of remdesivir discovered
The virostatic agent remdesivir was developed to disrupt an important step in the propagation of RNA viruses, to which SARS-CoV-2 also belongs: the reproduction of the virus’s own genetic material. This is present as RNA matrices with which the host cell directly produces virus proteins. To accelerate the production of its own proteins, however, RNA viruses cause the RNA matrices to be copied. To do so, they use a specific protein of their own (an RNA polymerase), which is blocked by remdesivir. Strictly speaking, remdesivir does not do this itself, but rather a substance that is synthesized from remdesivir in five steps when remdesivir penetrates a cell.
The elaboration of laboratory protocols for the production of proteins is already the second milestone. Pixabay
A worldwide network of scientists has isolated functional units of the SARS-CoV-2 proteins in such a way that their structure, function, and interactions can now be characterized by researchers the world over and develop protocols to quickly spot mutations and new variants. The global consortium, led by researchers at Goethe University Frankfurt and TU Darmstadt, provides working protocols that will allow laboratories around the world to work quickly and reproducibly on SARS-CoV-2 proteins and also the mutants to come.
When the Covid-19 virus mutates, this initially only means that there is a change in its genetic blueprint. The mutation may lead, for example, to an amino acid being exchanged at a particular site in a viral protein. In order to quickly assess the effect of this change, a three-dimensional image of the viral protein is extremely helpful. “This is because
قدیمیترین کوزه عسل در آفریقای سیاه پیدا شد | دانش و محیط زیست | DW dw.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dw.com Daily Mail and Mail on Sunday newspapers.
Jürgen Habermas Named Sheikh Zayed Award Cultural Personality
The 15th iteration of the Sheikh Zayed Book Award gives its career achievement honor, Cultural Personality of the Year, to the German philosopher Jürgen Habermas.
Jürgen Habermas at the Munich School of Philosophy, 2008. Image: Wolfram Huke, CC by SA 3.0
‘A Pioneer of Critical Theory’
Capping its announcements of 2021 winners, the Sheikh Zayed Book Award in Abu Dhabi has named German philosopher Jürgen Habermas its Cultural Personality of the Year.
Along with the program’s other winners reported on April 22 this award is to be conferred during the annual awards ceremony in May during the Abu Dhabi International Book Fair, and will come with a medal, a certificate, and a cash award of 1 million UAE dirhams (US$272,257). That purse, along with 750,000 UAE dirhams (US$204,181) for winners of each of the eight book categories in the program, makes the Sheikh Zayed Book Award one of the wealthiest portfolios of p
Twist Bioscience Corporation: Twist Bioscience and Vivlion Partner to Generate gRNA Libraries for CRISPR Applications
Twist Bioscience Corporation (Nasdaq: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, and Vivlion GmbH, a company providing next-generation CRISPR gRNA libraries and screening services for the global R&D market, today announced a collaboration for the generation of gRNA libraries for CRISPR applications. CRISPR\Cas is a powerful functional genomics tool used for a wide range of applications including genome engineering and target discovery for drug development. Research using CRISPR continues to accelerate into many different areas. This collaboration combines Twist s ability to generate highly uniform long oligos at scale with Vivlion s ability to translate these into equally highly uniform CRISPR libraries for the next generation of high-throughput CRISPR screenings, said Emily M. Lep