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Study reveals the implication of lysosomes in the spread of Parkinson’s disease Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases pathogenesis, which is essential to develop efficient treatments against these incurable diseases. However, our knowledge about the basic molecular mechanisms underlying the pathogenesis of neurodegenerative diseases is still lacking. A team of researchers found out the implication of lysosomes in the spread of Parkinson s disease. The accumulation of misfolded protein aggregates in affected brain regions is a common hallmark shared by several neurodegenerative diseases (NDs). Mounting evidence in cellular and in animal models highlights the capability of different misfolded proteins to be transmitted and to induce the aggregation of their endogenous counterparts, this process is called seeding . In Parkinson

Institut pasteurChiara zurzoloEmily hendersonFrench national centre for scientific researchFrench national centreScientific researchMembrane trafficPathogenesis unitநிறுவனம் பாஸ்டர்எமிலி ஹென்டர்சன்பிரஞ்சு தேசிய மையம் க்கு அறிவியல் ஆராய்ச்சிபிரஞ்சு தேசிய மையம்அறிவியல் ஆராய்ச்சிசவ்வு போக்குவரத்து