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Credit: Dotted Yeti LA JOLLA, CALIF. - April 16, 2021 - Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body s frontline virus fighters. The study was published in the journal Molecular Cell. We wanted to gain a better understanding of the cellular response to SARS-CoV-2, including what drives a strong or weak response to infection, says Sumit K. Chanda, Ph.D., professor and director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys and lead author of the study. We ve gained new insights into how the virus exploits the human cells it invades, but we are still searching for its Achille s heel so that we can develop optimal antivirals.

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