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T cells can be engineered to fight tumors without succumbing to exhaustion Fighting a tumor is a marathon, not a sprint. For cancer-fighting T cells, the race is sometimes just too long, and the T cells quit fighting. Researchers even have a name for this phenomenon: T cell exhaustion. In a new Nature Immunology study, researchers at La Jolla Institute for Immunology (LJI) report that T cells can be engineered to clear tumors without succumbing to T cell exhaustion. The idea is to give the cells a little bit of armor against the exhaustion program. The cells can go into the tumor to do their job, and then they can stick around as memory cells.

Hyungseok seoPatrick hoganManjana raoEmily hendersonRao labJolla institute for immunologyNature immunologyபேட்ரிக் ஹோகன்அஞ்சனா ராவ்எமிலி ஹென்டர்சன்ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்புஇயற்கை நோயெதிர்ப்பு