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Representative Image | Pixabay Cells sense and respond to the mechanical properties of the cellular microenvironment in the body. Changes in these properties, which occur in a number of human pathologies, including cancer, can elicit abnormal responses from cells but how the cells adapt to such changes in the mechanical microenvironment is not well understood. A team of researchers at Texas A and M University are working to understand cellular mechanosensing- the ability to sense and respond to the mechanical properties of the microenvironment- in a unique way. Dr Tanmay Lele, Unocal Professor in the Department of Biomedical Engineering, Department of Chemical Engineering and the Department of Translational Medical Sciences, partnered with Dr Charles Baer, an evolutionary biologist at the University of Florida. Together they used methods of experimental cellular evolution as a means to understand cellular adaptation to biomaterials of controlled mechanical properties.

United statesCharles baerTanmay lelePurboja purkayasthaKavya pendyalaArtie mcferrin department of chemical engineeringDepartment of chemical engineeringUniversity of floridaDepartment of biomedical engineeringM universityDepartment of biomedical engineering at texasDepartment of translational medical sciencesUnocal professorBiomedical engineeringChemical engineeringTranslational medical sciences