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New Orleans, LA - Research conducted by an international team of scientists discovered a mechanism that leads to Herceptin resistance, representing a significant clinical obstacle to successfully treating HER2-positive breast cancer. They also identified a new approach to potentially overcome it. The work is published online in
Nature Communications, available here. This work attempts to understand why some HER2-positive breast cancer patients do not benefit from treatment with Herceptin, which is a generally effective HER2-targeted therapy, explains Bolin Liu, MD, Professor of Genetics at LSU Health New Orleans School of Medicine and Stanley S. Scott Cancer Center.
Chinese Academy of Sciences
Recently, the research group led by Prof. YU Ziniu from the South China Sea Institute of Oceanology (SCSIO) of the Chinese Academy of Sciences sequenced the first complete Natuilus genome and unveiled the evolutionary features underlying the pinhole eye formation and biomineralization.
This study was published in Nature Ecology & Evolution on May 10.
Nautilus is the only surviving externally shelled cephalopod since the Palaeozoic. They have preserved many ancestral features despite a long evolutionary history, such as a chambered shell and pinhole eye.
The researchers sequenced the complete genome of N. pompilius, which is the most widespread species among nautiluses. The genome was 730.58 (Mb) in size and encoded 17,170 protein-coding genes, presenting a most compact, simple and slow-evolving genome when compared to other coleoid cephalopods.
Residential coal use in China results in many premature deaths, models indicate acs.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from acs.org Daily Mail and Mail on Sunday newspapers.
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Earthworms improve the soil by aerating it, breaking down organic matter and mineralizing nutrients. Now, researchers reporting in ACS
Environmental Science & Technology have dug up another possible role: reducing the number and relative abundance of antibiotic-resistance genes (ARGs) in soils from diverse ecosystems. These results imply that earthworms could be a natural, sustainable solution to addressing the global issue of antibiotic resistance, the researchers say.
The overuse of antibiotics in humans and animals has caused ARGs to accumulate in soils, which could contribute to the rise in antibiotic-resistant infections. Earthworms consume tons of soil per year worldwide, and their guts have a unique combination of low-oxygen conditions, neutral pH and native microbial inhabitants that could have an effect on ARGs. However, the role of earthworms in the spread of antibiotic resistance has been controversial. Some studies in controlled settings suggest that their g