Forward Jet-tracking Components Installed at RHIC s STAR Detector bnl.gov - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bnl.gov Daily Mail and Mail on Sunday newspapers.
The COVID-19 pandemic caused by the SARS-CoV-2 virus continually poses serious threats to global public health. The main protease (Mpro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing Mpro inhibitors derived from either Boceprevir or Telaprevir, both of which are approved antivirals. All compounds inhibited SARS-CoV-2 Mpro activity in vitro with IC50 values ranging from 7.6 to 748.5 nM. The co-crystal structure of Mpro in complex with MI-23, one of the most potent compounds, revealed its interaction mode. Two compounds (MI-09 and MI-30) showed excellent antiviral activity in cell-based assays. In a SARS-CoV-2 infection transgenic mouse model, oral or intraperitoneal treatment with MI-09 or MI-30 significantly reduced lung viral loads and lung lesions. Both also displayed good pharmacokinetic properties and safety in rats.
2 emissions. Since CO
2 is thermodynamically stable, efficient catalysts are needed to reduce the energy consumption in the process.
The single-atom catalysts immobilized on nitrogen-doped carbon supports (M-N/C) have been widely used for CO
2 electrocatalytic reduction reaction due to their high atom utilization efficiency.
Recently, a research team led by Prof. LIU Licheng from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) proposed a two-step amination strategy to regulate the electronic structure of M-N/C catalysts (M=Ni, Fe, Zn) and enhance the intrinsic activity of CO
2 electrocatalytic reduction.
4/C was aminated by annealing with carbamide in NH
CUHK Physicists Discover New Route to Active Matter Self-Organisation Provides New Directions on Fabricating Self-driven Devices and Microbial Physiology
An international team led by Professor Yilin Wu, Associate Professor of the Department of Physics at The Chinese University of Hong Kong (CUHK) has made a novel conceptual advance in the field of active matter science. The team discovered a new route in which the self-organisation of active fluids in space and time can be controlled by a single material property called viscoelasticity. This new finding may pave the way for fabricating a new class of self-driven devices and materials, such as the ability to control the rhythmic movement of soft robots without relying on electronic circuits, and for the study of microbial physiology. It has been published in the scientific journal Nature.
E-Mail
IMAGE: Left: Frozen waterfall in a rural area west of Beijing, China (photo taken by Fei Zheng on Feb 17); Right: A snow-capped car in Austin, Texas USA (photo taken by. view more
Credit: Fei Zheng/ Zong-Liang Yang
China is just one of many countries in the Northern Hemisphere having what researchers are calling an extremely cold winter, due in part to both the tropical Pacific and the Arctic, according to an analysis of temperatures from Dec. 1, 2020, to mid-January of 2021. A country-specific case study, the investigation potentially has far-reaching implications for predictions and early warnings to protect against harmful impacts, researchers said.