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Role of cell cycle on analyzing telomerase activity with a fluorescence off-on system

 E-Mail IMAGE: AIEgen-based fluorescence detecting system for analysis of TERT mRNA and telomerase activity in different phases of cell cycle (G0/G1, G1/S, S and G2/M phase). view more  Credit: @Science China Press Cancer is a significant cause of death worldwide and many efforts have been devoted to the development of methods for early detection. Telomerase are considered as a tumor biomarker for early diagnosis because the telomerase of more than 80% immortalized cells are reactivated and provides the sustained proliferative capacity of these cells, but the telomerase activity are not detectable in normal somatic cells. Telomerase is a ribonucleoprotein complex that is thought to add telomeric repeats onto the ends of chromosomes during the replicative phase (S phase) of the cell cycle.

Load-reducing backpack powers electronics by harvesting energy from walking

 E-Mail IMAGE: A prototype backpack harvests energy from walking to power small electronics, and it makes loads feel lighter. view more  Credit: Adapted from 2021, DOI: 10.1021/acsnano.0c07498 Hikers, soldiers and school children all know the burden of a heavy backpack. But now, researchers have developed a prototype that not only makes loads feel about 20% lighter, but also harvests energy from human movements to power small electronics. The new backpack, reported in ACS Nano, could be especially useful for athletes, explorers and disaster rescuers who work in remote areas without electricity, the researchers say. Backpacks are widely used in everyday life for the hands-free carrying of loads. Over time, however, walking or running with a heavy sack can cause back and neck pain. Also, backpackers in wilderness areas (or even those in cities who don t have ready access to a charger) might wish for a bag that could harvest the mechanical energy of walking to power p

Frontiers | Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage

1Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China 2Luzhou Key Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China 3Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China 4Sichuan Clinical Research Center for Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China Subarachnoid hemorrhage (SAH) is a devastating form of stroke, which poses a series of intractable challenges to clinical practice. Imbalance of mitochondrial homeostasis has been thought to be the crucial pathomechanism in early brain injury (EBI) cascade after SAH. Irisin, a protein related to metabolism and mitochondrial homeostasis, has been reported to play pivotal roles in post-stroke neuroprotection. However, whether this myokine can exert neuroprotection effects after SAH remains unknown. In t

Gene mutations linked to worse leukemia outcomes in Hispanic and Latino children

Gene mutations linked to worse leukemia outcomes in Hispanic and Latino children A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers. They said a novel therapeutic drug combination as well as testing for these mutations may help address the disparity. Hispanic and Latino children are between 1.2 and 1.75 times more likely to develop B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, than non-Hispanic and Latino children. They also have a 40% higher death rate than their counterparts after correcting for socioeconomic factors. Dr. Sinisa Dovat, a researcher and pediatric oncologist at Penn State Children’s Hospital and Penn State Cancer Institute, partnered with Dr. Gordana Raca of Children’s Hospital Los Angeles and Kimberly J. Payne of Loma Linda University to understand the biology behin

Will Silicon Valley tech overlords censor the Chinese government s COVID conspiracy theories also?

https://www.afinalwarning.com/493529.html (Natural News) Chinese state media – which spills onto US social media platforms has become a hotbed of COVID-19 conspiracy-mongering in the past year. Will the Silicon Valley tech overlords apply the same standards to the Chinese Communist Party that they apply to average Americans? (Article by Sundance republished from TheDailyBell.com) The CCP has trotted out a compendium of next-level Pizzagate-caliber, officially-endorsed conspiracy theories designed to obfuscate their own complicity in the coronavirus epidemic that originated in Wuhan. Anti-American Korean War-era CCP propaganda poster. The CCP has facilitated a renewed population-wide lust for anti-American propaganda in the past 2 years.

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