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GIP/GLP-1 RA Phase III Success; USPSTF Looking for Input

email article Eli Lilly said the SURPASS-3 and SURPASS-5 phase III clinical trials showed that the once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist tirzepatide significantly reduced HbA1c and body weight in adults with type 2 diabetes meeting both trials primary and key secondary endpoints. In other trial success, the SKYLIGHT 1 and SKYLIGHT 2 phase III clinical trials also met all their primary endpoints with the investigational, oral, nonhormonal compound fezolinetant for moderate to severe vasomotor symptoms of menopause, Astellas announced. Girls with overweight and obesity tended to have higher levels of certain hormones like follicle-stimulating hormone, inhibin B, and testosterone during puberty compared with normal weight girls. In some girls with higher total body fat, higher testosterone levels were associated with irregular menstrual cycles, acne, and excess body hair, added study author Natalie Shaw, MD,

Black, Hispanic families hit hardest by dementia | News, Sports, Jobs

(Image courtesy of Metro Creative) It can begin with the occasional missed bill payment. An inability to remember names. Telling the same story repeatedly. There may be personality changes or mood swings. Confusion. Over time, it’s as if the person who once was slowly disappears. Dementia. As the population ages, a growing number of families face this debilitating condition, which can be both emotionally and financially exhausting, and require near-constant supervision from spouses or adult children. It can be tough on any family, but in the United States, Black and Hispanic communities are hardest hit. “We don’t exactly know why,” said Jason Resendez, executive director for the UsAgainstAlzheimer’s Center for Brain Health Equity in Washington, D.C. “More and more evidence is pointing to a mix of factors that are health-related, such as disparities in diabetes and heart disease. But there are also social and economic factors, such as education, social isolation, smokin

Hazel Johnson, the mother of environmental justice, was Catholic

Hazel Johnson (1935-2011) is considered by many to be the mother of environmental justice. For more than 30 years, she pressed local officials and corporations to clean up toxic waste and pollution in her southeast Chicago community of Altgeld Gardens. (Courtesy of People for Community Recovery) She was a community activist. She was an ambassador of Altgeld Gardens. She was an early mentor to Barack Obama. She was a thorn in the side of the Chicago waste industry. She was a wife and mother of seven children. She is the mother of the environmental justice movement. For more than 30 years, Hazel Johnson worked to clean up her corner of Chicago s southeast side. Her relentless advocacy made her a fixture in local news, and her story has been told in profiles and books and kept alive among her peers in the struggle for environmental justice. But one aspect of her life that s been less explored is her faith.

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