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Study reveals link between changes of neuronal activities and dyskinesia

Study reveals link between changes of neuronal activities and dyskinesia Many people with Parkinson s disease develop abnormal movements called L-DOPA induced dyskinesia, a major side effect of long-term medication. The mechanism underlying this side effect has been unknown. In this study, researchers have revealed relation between changes of neuronal activities and dyskinesia. Parkinson s disease (PD) is the common age-related neurological disorder affecting 7 - 10 million people worldwide. It is caused by loss of dopaminergic neurons in the brain region called the substantia nigra, and induces difficulty in execution of movements (akinesia), muscle stiffness (rigidity), walking difficulty, tremorous hand movements (tremor), and non-motor symptoms such as depression and sleep disturbance.

Mechanism of abnormal movements induced by drug treatment of Parkinson s disease

Mechanism of abnormal movements induced by drug treatment of Parkinson s disease
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New method could democratize deep learning-enhanced microscopy

Loading video. VIDEO: A low-resolution time-lapse of a mitochondrial network (cell s powerhouse) inside a cancer cell (left) is enhanced using artificial intelligence (right). Inset at bottom left highlights a fission (splitting) event that. view more  Credit: Salk Institute/Waitt Advanced Biophotonics Core LA JOLLA (March 8, 2021) Deep learning is a potential tool for scientists to glean more detail from low-resolution images in microscopy, but it s often difficult to gather enough baseline data to train computers in the process. Now, a new method developed by scientists at the Salk Institute could make the technology more accessible by taking high-resolution images, and artificially degrading them.

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