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Identifying rare genetic variants that increase risk for lung cancer

Identifying rare genetic variants that increase risk for lung cancer
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Skeletal Dysplasia Market Worth $ 3 10 Bn By 2028 | CAGR: 4 06% - Media Releases

On-the-Spot Gene Readouts Offer Clues to How Cells Work

Posted on Credit: MIT and Harvard Medical School, Cambridge, MA Just as two companies can merge to expand their capabilities, two technologies can become more powerful when integrated into one. That’s why researchers recently merged two breakthrough technologies into one super powerful new method called ExSeq. The two-in-one technology enables researchers for the first time to study an intact tissue sample and track genetic activity on the spot within a cell’s tiniest recesses, or microenvironments areas that have been largely out of reach until now. ExSeq, which is described in a paper in the journal Science [1], will unleash many new experimental applications. Beyond enabling more precise analysis of the basic building blocks of life, these applications include analyzing tumor biopsies more comprehensively and even unlocking mysteries of how the brain works. The latter use is on display in this colorful cross-section of a mouse’s hippocam

Dana-Farber research leads to better understanding of immune system in kidney cancer

Date Time Dana-Farber research leads to better understanding of immune system in kidney cancer Two research papers highlight single-cell dissection of kidney tumors to identify new immunotherapy treatments and targets In the last two decades, immunotherapy has emerged as a leading treatment for advanced renal carcinoma cancer (more commonly known as kidney cancer). This therapy is now part of the standard of care, but it doesn’t work for all patients, and almost all patients, no matter how they respond initially, become more resistant to treatment over time. The immune system plays a critical role in kidney cancer disease progression and in response to therapies, and so a fundamental challenge in the field is to understand the underlying “immune circuitry” of this disease.

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