A Step Toward Light Therapy: Discovery of Indigo Ion Channel Switch Expands Optogenetic Toolkit
April 30, 2021
KnChR allows sodium ions and calcium ions to pass through in the presence of indigo light. [Hideki Kandori, Nagoya Institute of Technology]
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Channels with walls of protein through which charged atoms cruise across biological barriers are called ion channels. Scientists have discovered a new ion channel that can be switched on and off by indigo blue light, the shortest wavelength of light that can be used to operate any ion channel discovered to date.
Channelrhodopsins (ChRs) are ion channels found in green algae that allow the selective passage of charged atoms (ions) and can be opened or closed directly by shining light of specific wavelengths on them. The discovery of ChRs has opened a new field of research in neuroscience, optogenetics the application of light to modulate cellular and genetic functions that aspires to cure maladies from blindness to Alzheimer
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