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Structuring the cerebral neocortex

Structuring the cerebral neocortex
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Victor tarabykinMarta rosInstitute of cell biologyCell biologyநிறுவனம் ஆஃப் செல் உயிரியல்செல் உயிரியல்

Cancer mutations insight could boost detection and personalize treatments

Cancer mutations insight could boost detection and personalize treatments
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United statesUnited kingdomCity ofMarie anne robertsonGiovanni stracquadanioSchool of biological sciencesCancer researchAmerican association for cancer researchInstitute of cell biologyScience communicationsUniversity of edinburghAmerican associationBayesian geneUnited kingdom biobankSenior lecturerSynthetic biology

Anti-emetic drug offers a promising approach to treat chronic myeloid leukemia

Anti-emetic drug offers a promising approach to treat chronic myeloid leukemia Chronic myeloid leukemia (CML) results from a degeneration of the hematopoietic stem cells (leukemia stem cells), thereby leading to the uncontrolled formation of specific white blood cells, the so-called granulocytes. Research work at the Department of Medical Oncology at the Inselspital, Bern University Hospital and the University of Bern focused therefore on identifying the signaling pathways and control mechanisms of the leukemia stem cell. A promising approach is provided by working with MPR, an anti-emetic medication commonly used to treat nausea and vomiting. Specific blocking of leukemia stem cell proliferation with metoclopramide

Carsten rietherEmily hendersonUniversity hospitalDepartment of medical oncologyInstitute of cell biologyDepartment of orthopedic surgeryBern university hospitalUniversity of bernDepartment for biomedical researchMedical oncologyBiomedical researchCell biologyOrthopedic surgeryStem cellsCell proliferationChronic myeloid leukemia

Metoclopramide inhibits proliferation of leukemia stem cells

E-Mail Chronic myeloid leukemia (CML) results from a degeneration of the hematopoietic stem cells (leukemia stem cells), thereby leading to the uncontrolled formation of specific white blood cells, the so-called granulocytes. Research work at the Department of Medical Oncology at the Inselspital, Bern University Hospital and the University of Bern focused therefore on identifying the signaling pathways and control mechanisms of the leukemia stem cell. A promising approach is provided by working with MPR, an anti-emetic medication commonly used to treat nausea and vomiting. Specific blocking of leukemia stem cell proliferation with metoclopramide The exact role of the surface molecule CD93 (cluster of differentiation 93) in controlling the proliferation of leukemia stem cells was analyzed and documented, initially in animal experiments and subsequently in experiments with leukemia stem cells from patients. This revealed a distinct regulatory function of CD93 in leukemia stem cel

Carsten rietherUniversity hospitalDepartment of medical oncologyInstitute of cell biologyDepartment of orthopedic surgeryBern university hospitalUniversity of bernDepartment for biomedical researchMedical oncologyBiomedical researchCell biologyOrthopedic surgeryMedicine healthபல்கலைக்கழகம் மருத்துவமனைதுறை ஆஃப் மருத்துவ புற்றுநோயியல்நிறுவனம் ஆஃப் செல் உயிரியல்