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Researchers develop new exosome formulation to deliver VEGF antibodies for synergistic therapy Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences, Beijing Chaoyang Hospital and the University of Queensland have developed a new formulation based on regulatory T-cell exosomes (rEXS) to deliver vascular endothelial growth factor (VEGF) antibodies for choroidal neovascularization therapy. The study was published in Nature Biomedical Engineering on July 26. Ocular neovascularization is often associated with age-related macular degeneration, diabetic retinopathy and other ocular diseases, which can cause severe vision loss. The present treatment for ocular neovascular disease in clinic is intravitreal injection of VEGF antibodies (aV) to block the activity of VEGF and suppress pathogenic angiogenesis. However, this therapy alone faces problems of fast metabolism with the aqueous humor, poor accumulation in lesions and limited efficacy. A co

Emily hendersonUniversity of queenslandInstitute of process engineeringChinese academy of sciencesProcess engineeringChinese academyBeijing chaoyang hospitalNature biomedical engineeringBeijing chaoyangஎமிலி ஹென்டர்சன்பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்துநிறுவனம் ஆஃப் ப்ரோஸெஸ் பொறியியல்சீன கலைக்கழகம் ஆஃப் அறிவியல்ப்ரோஸெஸ் பொறியியல்சீன கலைக்கழகம்இயற்கை உயிர் மருத்துவ பொறியியல்