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HIN Using viruses instead of antibiotics to tame troublesome drug-resistant bacteria is a promising strategy, known as bacteriophage or “phage therapy.” Scientists at the National Institutes of Health have used two different bacteriophage viruses individually and then together to successfully treat research mice infected with multidrug-resistant Klebsiella pneumoniae sequence type 258 (ST258). The bacterium K. pneumoniae ST258 is included on a Centers for Disease Control and Prevention list of biggest antibiotic resistance threats in the United States. High rates of morbidity and mortality are associated with untreated K. pneumoniae infections. Phage therapy has been pursued for about a century, though conclusive research studies are rare and clinical results – from a handful of reports – have provided mixed results. In the new paper published in the journal mBio, the NIH scientists note that phages are of great interest today because of a dearth of alternative treatment op

Rocky mountainUnited statesNational institutes of healthCenters for diseaseNational cancer institute in bethesdaNational institute of allergyNational institutesDisease controlRocky mountain laboratoriesInfectious diseasesNational cancer instituteTreatment rescues mice infectedMultidrug resistant klebsiellaDiverse mutations that culminateAntibiotic resistanceபாறை மலை