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This is how the guardians of the genome work

National Cancer Research Center (CNIO) It has been discovered how certain proteins ensure Repair errors caused by DNA during replication. Use electronic cryoscopy to check, Rafael Fernandez Leiro Make visible Protein mutation, Also known as the “gatekeeper” of our genome, which allows them to describe how this single protein coordinates this important DNA repair process from start to finish. The research is related to Med Lammers, Leman University Medical Center, LUMC (Netherlands) and Titia Sixma, From the Netherlands Cancer Institute and Oncode Research Institute.Their results are published in Natural structure and molecular biology. Between different stages Cell division There is DNA replication, during which DNA polymerase replicates the genetic information of the cell to transfer it to daughter cells. Although the mechanism is very precise, errors occasionally occur. These errors must be repaired, otherwise it will cause tumors.

An international study reveals how the guardian of the genome works

 E-Mail IMAGE: The background of the illustration is a photograph taken with the electron microscope showing DNA molecules decorated with MutS molecules, scanning the DNA for errors. The lower part shows. view more  Credit: CNIO Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre (CNIO) have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication. Using cryo-electron microscopy, they made the MutS protein, also known as the guardian of our genome, visible. That enabled them to describe how this single protein is able to coordinate the essential DNA repair process from beginning to end.

Israeli Breakthrough: Cancer Cell Bacteria Can Fight Tumors

Apr 1, 2021 Scientists have discovered that the immune system can find bacteria residing within cancer cells and use them to provoke an immune reaction against a tumor. By Abigail Klein Leichman, Israel21c The immune system can find bacteria residing within cancer cells and harness them to provoke an immune reaction against the tumor, according to a study published in Nature. An international research team, led by researchers from the Weizmann Institute of Science in Israel, says this discovery may explain why the gut microbiome is known to affect the success of immunotherapy treatments for cancer. Immunotherapy has dramatically improved recovery rates from certain cancers, particularly malignant melanoma, but still work in only about 40 percent of the cases.

Cancer Core Europe s design and development of data rich, dynamic studies in oncology

Cancer Core Europe s design and development of data rich, dynamic studies in oncology
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