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Emerging Lessons From COVID-19 for the US Clinical Research Enterprise | Research, Methods, Statistics | JAMA

Perrine Janiaud, PhD; Cathrine Axfors, MD, PhD; Andreas M. Schmitt, MD; Viktoria Gloy, PhD; Fahim Ebrahimi, MD, MSc; Matthias Hepprich, MD; Emily R. Smith, ScD, MPH; Noah A. Haber, ScD; Nina Khanna, MD; David Moher, PhD; Steven N. Goodman, MD, PhD; John P. A. Ioannidis, MD, DSc; Lars G. Hemkens, MD, MPH In this issue of JAMA, Janiaud et al 1 present a meta-analysis of randomized clinical trials (RCTs) of convalescent plasma for the treatment of patients with COVID-19. Based on an analysis of 1060 patients from 4 RCTs published in peer-reviewed journals and 10 722 patients from 6 RCTs (5 published as preprints and 1 as a press release), the authors found that treatment with convalescent plasma vs placebo or standard of care was not associated with a significant decrease in all-cause mortality (risk ratio, 0.93 [95% CI, 0.63-1.38] for the 4 peer-reviewed RCTs; risk ratio, 1.02 [95% CI, 0.92-1.12] for all 10 RCTs) or with benefit for other clinical outcom

Campbell faculty appointed to distribute $22M in research funds | News

February 23, 2021 Dr. Miranda van Tilburg, professor of Clinical Research at Campbell University, adjunct Professor of Medicine at UNC and affiliate professor of social work at the University of Washington, was recently appointed as a reviewer for the Patient-Centered Outcomes Research Institute (PCORI). PCORI is part of the National Institute of Health (NIH) and focuses on finding effective therapies that help narrow down which treatment or solution might be best in a given situation. Similar to the NIH, people apply to PCORI for research-based grants. Appointed review panels then review grant applications and choose a recipient. These panels are sometimes formed to review specific applications based on a reviewer’s area of expertise.

Losing Obamacare protections during pandemic could increase health disparities

 E-Mail If Affordable Care Act protections for pre-existing condition coverage are no longer available, the coronavirus pandemic would leave many Americans - a disproportionate number of whom are people of color - without health insurance, a new Oregon Health & Science University study indicates. Published in the Journal of the American Board of Family Medicine, the study s findings reveal a third of the more than 7,500 COVID-19 patients who received care at U.S. community health centers between March and October 2020 did not have a pre-existing condition prior to contracting the novel coronavirus. People of color made up at a significant portion of the COVID-19 patients studied: 51 percent were non-Hispanic Asian, 36 percent Hispanic, and 28 percent non-Hispanic Black. In comparison, the U.S. Census reports America s 2019 population was about 5.9 percent Asian alone, 18.5 percent Hispanic, and 13.4 percent Black alone.

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