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IMAGE: A bovine egg after fertilization: The parental genomes are still located in two separate pronuclei. Before unification, the chromosomes (magenta) cluster at the pronuclear interface. Part of the cytoskeleton is. view more
Credit: MPI for Biophysical Chemistry/ Tommaso Cavazza and Melina Schuh
Only one in three fertilizations leads to a successful pregnancy. Many embryos fail to progress beyond early development. Cell biologists at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen (Germany), together with researchers at the Institute of Farm Animal Genetics in Mariensee and other international colleagues, have now developed a new model system for studying early embryonic development. With the help of this system, they discovered that errors often occur when the genetic material from each parent combines immediately after fertilization. This is due to a remarkably inefficient process.