SNP-Chip: CRISPR-Based Transistor Detects Single Point Mutations SNP-Chip enables amplification-free, electronic, detection of point mutations in DNA from patients with Sickle-Cell Disease and ALS
Long before the COVID-19 pandemic shined a spotlight on CRISPR-based diagnostics, Kiana Aran, PhD, was developing the CRISPR-Chip. It was, according to Aran, the first transistor that uses CRISPR to search the genome for potential mutations. In addition, the graphene field-effect transistor (gFET) did not require amplification or sequencing of the nucleic acid.
Now, two years after its introduction, a group headed by Aran, co-founder and CSO at Cardea Bio, and assistant professor at the Keck Graduate Institute of Applied Life Sciences, is introducing an improved CRISPR-based gFET system, named SNP-Chip.
Codagenix Expands Senior Management Team With Three New Appointments
New Hires Bolster Codagenix s Operations, Regulatory Affairs and Clinical Trial Management
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NEW YORK, March 17, 2021 /PRNewswire/ Codagenix Inc., a clinical-stage biotechnology company developing prophylactic vaccines and oncolytic virus therapies, today announced the expansion of its senior management team with three new appointments. Lisa Runco, Ph.D., has been named Director of Operations. Additionally, Sally Yang, M.S., R.A.C. has been appointed Associate Director of Regulatory Affairs, and Lasmy Tea, M.S., M.P.H., has been named Associate Director of Clinical Project Management.
Tunnel construction as a climate-friendly source of energy
The Brenner Base Tunnel will relieve transit traffic between Italy and Austria and, incidentally, supply parts of Innsbruck with geothermal energy. The source of energy is the tunnel water.
17 March 2021
Brenner Basistunnel (c) BBT SE
When tunnels are bored through mountains, it is not the groundwater level that is an issue but the mountain water level. Mountain water comes from precipitation and flows down from the mountain surface. Along the way, its temperature is increased by the earth’s heat.
“Geothermal energy is largely generated by the decay of long-lived nuclides in the earth’s interior,” says Thomas Geisler of the Institute of Rock Mechanics and Tunneling at Graz University of Technology. “As such, it is an entirely natural heat source fed by the Earth’s interior.” Unlike wind turbines, which only provide energy when the wind is blowing, geothermal energy is basically available around the clock an
12 March 2021
Using a large fleet of small modular reactors (SMR) to secure climate neutral electricity supply in the future – as proposed by billionaire and philanthropist Bill Gates – poses many unsolved problems and security risks, two researcher assessments commissioned by the Federal Office for the Safety of Nuclear Waste Management (BASE) have found according to a report by Süddeutsche Zeitung (SZ).
SMR proponents claim that, once produced in bulk, these small plants are cheaper and safer thanks to advanced reactor designs and can be operated with converted short-lived radioactive materials, solving the waste problem.
But the two reports, seen by SZ, conclude that SMR “carry enormous risks with regard to the proliferation of weapons-grade materials and will probably never be as cheap as their advocates claim”, Michael Bauchmüller writes.
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