Dengue virus infection is prevalent in tropical and sub-tropical regions of the world, which is fatal if untreated symptomatically. Emergence of new genotype within serotypes led to enhanced severity. The objective of the study is to identify the molecular characteristics of the DENV circulated during 2017 outbreak in Tamil Nadu, India and, to investigate the role of inflammatory cytokines in different ‘serotypes’ and in ‘dengue severity’. A total of 135 suspected samples were tested for DENV infection using IgM, IgG and qPCR assay; where 76 samples were positive for DENV and analysed for twelve inflammatory cytokines using ELISA. Serotyping shows 14 DENV-1, 22 DENV-2, 7 DENV-3 and 33 DENV-4, where DENV-4 was predominant. Among seventy-six, forty-two isolates were successfully sequenced for C-prM region and grouped. A lineage shift was observed in DENV-4 genotype. Irrespective of serotypes, IFNγ was significantly elevated than control and in primary infection indicating its ro
An investigation finds the former anthropology professor “engaged in unwelcome sexual conduct and abused power,” among other violations of institutional policies and values
Guillermo S. Hava â24, a Crimson Associate Editorial editor, lives in Winthrop House. His column appears on alternate Wednesdays.
For the past eight months or so, Iâve been writing a column based on the premise that Harvard is effectively âFor Sale,â arguing, week after week, that our numerous controversial financial ties are improper of our institution. Iâve tried to claim the self-aggrandizing high ground on everything ranging from the opioid epidemic to tyrannical regimes â quite the unrealistic effort for an exiled freshman Spaniard.
But what if the crux of my column turned out to be, simply put, incorrect? What if tainted donations were, like Harvard insists, merely the means to a noble end?
Access to COVID-19 vaccines: Global approaches in a global crisis
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Abstract
Following the extraordinarily rapid development of COVID‑19 vaccines, immunisation is underway in many OECD countries. However, demand will continue to outstrip supply for some time and currently, distribution is strongly skewed in favour of high-income countries. This both inequitable and inefficient. Directing vaccine to where need is greatest would maximise the number of lives saved and speed bringing the pandemic under control, by slowing transmission and reducing the likelihood of the emergence of viral variants of concern. Governments should therefore act now to accelerate vaccination globally, regardless of international borders, by reallocating supplies to areas of greatest need; continuing the scaling-up of production; ensuring that necessary logistics and health care infrastructure are in place; providing further financial and in-kind support to COVAX; and developing long-term strategies tha