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Large Epigenome Study Finds Hundreds Of Alzheimer s-Linked Sites

Diego Mastroeni, assistant research professor at ASU s Banner Neurodegenerative Disease Research Center. The onset and advancement of Alzheimer’s disease (AD) is affected not only by a patient’s genes but also by the molecular switches that turn them on and off. Now, one of the largest studies of these controls, know collectively as the epigenome, offers scores of possible AD treatment targets. The meta-study, led by Katie Lunnon of the University of Exeter Medical School in the United Kingdom, appears in the journal Nature Communications. Co-author Diego Mastroeni of the ASU-Banner Neurodegenerative Disease Research Center says the epigenome is a promising treatment toolkit because it’s far easier to manipulate than DNA.

A once-in-a-generation advance

Thrombectomy is, by many accounts, a game-changing procedure in the treatment of strokes. It involves using a specially designed clot removal device or stent, manipulated through a fine catheter in an artery in the groin, to pull or suck out a clot lodged in an artery in the brain to restore blood flow. If delivered quickly, research has found that a thrombectomy can significantly reduce the risk of death or disability from a stroke. Despite this, the procedure’s roll-out across the UK has been much slower than elsewhere in Europe and the US. Here, Martin James, consultant stroke physician at the Royal Devon and Exeter Hospital, and honorary clinical professor at the University of Exeter Medical School, gives his thoughts on how to overcome some of the challenges behind this slow uptake.

Southend: Dr Bharat Pankhania on the Covid vaccine

Contracting Covid-19 Dr Pankhania added: “Just because these vaccines were created in less than a year does not mean corners were cut. They are as safe as any vaccine that has been released out in the field. “We have identified some vary rare concerns with the AZ vaccine and this is a good result of post-vaccine surveillance which has managed to pick up an unbelievably, unexpectedly rare link between blood clots and vaccine in a very, very number of people.” Dr Pankhania went on to reject the theory that maintain good health alone will prevent people from becoming infected with coronavirus.

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