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Frustration could be additional factor in substance use disorders, claims study
aninews.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from aninews.in Daily Mail and Mail on Sunday newspapers.
Study shows how mutant protein clusters drive disease-causing aggregates
A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called “the guardian of the genome,” is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors.
Researchers led by Peter Vekilov at the University of Houston (UH) and Anatoly Kolomeisky at Rice University have discovered the same mutant protein can aggregate into clusters. These in turn nucleate the formation of amyloid fibrils, a prime suspect in cancers as well as neurological diseases like Alzheimer’s.
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IMAGE: James Crowe, Jr., MD, director of the Vanderbilt Vaccine Center (VVC) and Ann Scott Carell Professor in the Departments of Pediatrics and Pathology, Microbiology and Immunology at Vanderbilt. view more
Credit: Vanderbilt University Medical Center
A monoclonal antibody cocktail developed at Vanderbilt University Medical Center (VUMC) to neutralize the COVID-19 virus is effective against all known strains, or variants, of the virus, according to a report published in the journal
Nature Medicine.
That was one of the findings reported by a multi-institutional team led by researchers at Washington University School of Medicine in St. Louis.
In cell-culture studies, the researchers determined the ability of monoclonal antibodies as well as antibodies isolated from the convalescent plasma of previously infected people to neutralize highly transmissible variants of the SARS-CoV-2 virus that have arisen in the United Kingdom, South Africa, Brazil and else
Frustration is an additional factor of addiction: Study
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Study reveals frustration could be an additional factor of addiction ANI | Updated: Mar 04, 2021 09:03 IST
Washington [US], March 4 (ANI): A new study focused has found that frustration could be an additional factor in substance use disorders.
The findings of the study were published in the journal Psychopharmacology . A team from The University of Texas Medical Branch at Galveston (UTMB), which focused on drug addiction research, has pioneered a new way to study frustration as a factor in substance use disorders.
Traditional addiction research has focused on three aspects of substance use disorders: craving, impulsivity, or habit. Scientists hypothesized that a fourth factor, frustration, could also lead to an escalation of drug use and addiction.
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