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IMAGE: Marburg virus-like-particles (in green, which are not infectious) bud, or exit from the surface of a host cell. A host protein (in yellow) helps the VLPs bud. Research by Penn. view more
Credit: Penn Vet Microscopy Core Facility
The Marburg virus, a relative of the Ebola virus, causes a serious, often-fatal hemorrhagic fever. Transmitted by the African fruit bat and by direct human-to-human contact, Marburg virus disease currently has no approved vaccine or antivirals to prevent or treat it.
A team of researchers is working to change that. In a new paper in the journal
Antimicrobial Agents and Chemotherapy, investigators from Penn s School of Veterinary Medicine, working together with scientists from the Fox Chase Chemical Diversity Center and the Texas Biomedical Research Institute, report encouraging results from tests of an experimental antiviral targeting Marburg virus. The compound blocks the virus from departing infected cells, thus putting
Dr Kathryn Wotman will explore equine vision in a webinar in The Love of the Horse series.
Understanding how the horse sees and symptoms of eye problems will be under discussion in a free webinar in the “For the Love of the Horse” series created by
The Competitive Equestrian.
In “How Your Horse Sees It: Understanding Equine Vision”, ophthalmology expert Dr Kathryn Wotman will provide an overview on the function of the equine eye, dispel some of the common myths about how horses see and help horse owners understand symptoms that may mean a horse has a vision or eye problem.
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When horses haven’t eaten for at least 10 hours, the numbers of bacteria and bacterial species in their digestive system drop significantly.
Fortunately, though, healthy horses can get that microbiotal richness back within a day of eating normally. Even so, owners, veterinarians, and researchers alike need to be aware of the kinds of changes that happen in horses’ guts when they’re fasted, said Louise Southwood, BSc (Vet), Dipl. ACVS, ACVECC, a professor in emergency medicine and critical care at the University of Pennsylvania’s School of Veterinary Medicine, in Kennett Square.
“Withholding food for a day definitely changes the microbiota, but it’s important to keep in mind that this is very reversible,” Southwood said. “Within 24 hours (after fasting ends), it can come back to normal.”
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