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Why does heart scarring cause abnormal rhythms in some people but not others?

 E-Mail Scientists have shed light on why some people who have a stroke do not also have abnormal heart rhythms, even though their hearts contain similar scar tissue. Their results, published today in eLife, could help identify the best treatments for people who might be at risk of recurrent stroke, new heart disorders, or both. Strokes are often caused by abnormal blood flow resulting from rapid, irregular beating in the upper chamber of the heart. This is also called atrial fibrillation (AFib). But some people have strokes that appear to have been caused by the heart, yet there is no evidence of AFib. In fact, around 25% of strokes fall into this group - called embolic strokes of undetermined source (ESUS).

New class of drug gives hope to some ovarian cancer patients

The intersection of child poverty with race, immigrant status and environmental threats

 E-Mail IMAGE: The Pediatric Academic Societies (PAS) Meeting connects thousands of pediatricians and other health care providers worldwide. view more  Credit: PAS A state of the art plenary session during the Pediatric Academic Societies (PAS) 2021 Virtual Meeting will bring together national experts on child poverty, racism and racial inequities, immigrant health, Native American culture, and environmental threats to discuss the intersectionality of child poverty. Poor children do not just suffer from double jeopardy, but frequently multiple jeopardy from many overlapping threats to their health and development. The COVID-19 pandemic has further unearthed and intensified these threats to children including loss of financial resources, loss of nutritional supports, loss of family members, and loss of educational opportunity.

How one SARS-CoV-2 protein keeps cells from fighting back

Greninger lab In SARS-CoV-2-infected cells (green), mRNA (red) is trapped in the nucleus. The blue represents the DNA of the nucleus. New research has uncovered a way SARS coronaviruses delay an immune defense against them. The coronavirus responsible for the SARS outbreak of 2003 and the one causing the current pandemic may prevent cells from responding to infection in a similar manner. They do this by making a viral protein that keeps molecules from moving through pores in the membrane that separates a cell nucleus from the surrounding cytoplasm. “With these pores blocked, infected cells can’t fight back,” said Dr. Alex Greninger, assistant professor of laboratory medicine and pathology at the University of Washington School of Medicine, who led the study. “Eventually, the cells are able to respond and mount a response, but the action of this protein gives the virus time to replicate and generate a large viral load.”

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