Tacke received a bachelor’s and a doctoral degree from the Technical University in Berlin in 1919 and 1921, respectively. In 1925 she became a researcher at the Physico-Technical Research Agency in Berlin, where she began collaborating with chemists Walter Noddack and Otto Carl Berg.
When Russian chemist Dmitry Mendeleyev proposed the periodic table of the chemical elements in 1871, he left gaps in places where he believed unknown elements would find their place. Two such gaps were below manganese at atomic numbers 43 and 75. Tacke, Noddack, and Berg set out to discover these two elements, and in 1925 they bombarded platinum and columbite ores with electrons, which collided with atomic nuclei that then emitted X-rays. The atomic number of an element could thus be deduced from the spectrum of X-rays that the nuclei emitted. They announced the detection of the two predicted elements: atomic number 43, which they called masurium, after the region in Prussia that Noddack had come from
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