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CoCID project aims to develop soft X-ray microscope for visualizing cellular origin of diseases

CoCID project aims to develop soft X-ray microscope for visualizing cellular origin of diseases CoCID (Compact Cell Imaging Device), a €5.7 million, four-year, pan-European research and innovation project, funded through Horizon 2020, has officially commenced. CoCID is focused on the development of a soft X-ray-based methodology that enables fast and inexpensive three-dimensional imaging of whole internal structure of intact biological cells. The objective of CoCID is to develop a lab-scale, soft X-ray microscope, which can be used as a research tool to help scientists to understand the cellular origin of diseases. The benefits of this compact imaging device will be demonstrated through a series of virology use cases that enable researchers to decipher critical changes in cell morphology induced by viruses, such as SARS-CoV-2, in their host cell with the aim to identify possible targets for therapy suppressing virus replication and/or cellular responses of relevance to the virus

Top 10 science anniversaries to celebrate in 2021

Centuries from now, 2021 will be celebrated as an anniversary year most noted for getting rid of 2020. It will be less remembered as a year featuring a diverse roster of scientific anniversaries, ranging from the 1300th birthday of a prolific writer to the 25th birthday of a celebrity sheep. Nevertheless, before too much of 2021 passes by, it’s time to name the Top 10 anniversaries worthy of celebration this year some obscure, some fairly famous, and one that had an unfair advantage helping to make it No. 1. 10. Elizabeth Blackwell, 200th birthday Born in England in 1821, Blackwell moved with her family to New York in 1832 and a few years later to Ohio, where she became a teacher in a boarding school. After the death of a close friend she began applying to medical schools, acquiring a bunch of rejections until Geneva College sent her an acceptance letter (apparently the faculty sought input from the school’s students, and they voted to accept her as a joke). But she showed u

Aging-US: Sulforaphane promotes C elegans longevity and healthspan

The authors used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. Sulforaphane increased the lifespan and promoted a health-related phenotype by increasing mobility, appetite and food intake and reducing lipofuscin accumulation. Mechanistically, sulforaphane inhibited DAF-2-mediated insulin/insulin-like growth factor signaling and its downstream targets AGE-1, AKT-1/AKT-2. This was associated with increased nuclear translocation of the FOXO transcription factor homolog DAF-16. In turn, the target genes sod-3, mtl-1 and gst-4, known to enhance stress resistance and lifespan, were upregulated. The results in this Aging-US research output, indicate that sulforaphane prolongs the lifespan and healthspan of

How Should the Citizens of Hong Kong Prepare for Dictatorship?

Thus, the population was shaken up, forced into silence, and left without any possible leaders of resistance. So it was that ‘wisdom’ was instilled, that former ties and friendships were cut off. ~Aleksandr Solzhenitsyn, I Can moral life survive dictatorship? When a government intimidates its subjects; when it sows mistrust among them; when it penalizes virtue and incentivizes servility, how might men and women keep faith with themselves and their fellows? Citizens of democratic states tend to ponder such questions, if at all, with a detached, even theoretical, interest. Dictatorships happened then or, if extant, occur over there. But in the once-free city of Hong Kong such insouciance has vanished.

European soft x-ray microscopy project begins at UCD

European soft x-ray microscopy project begins at UCD The project aims to develop a soft x-ray microscope that can help scientists to understand the cellular origin of diseases. A four-year research project focused on the development of a soft x-ray microscope has officially commenced today (2 February). Compact Cell Imaging Device (CoCID) is a €5.7m pan-European research and innovation project, which will use soft x-ray-based methodology to enable fast and inexpensive three-dimensional imaging of whole internal structures of intact biological cells. This could provide valuable information for researchers to understand the disease pathways of viruses and aid the development of novel therapeutics. The project team hopes to achieve this by developing a lab-scale, soft x-ray microscope.

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