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What Drives the Clinical Benefits Seen with SGLT2 Inhibitors?

Feb 5, 2021 Volume, volume, volume may be the answer As findings from trial after trial provide evidence of the clinical benefit of SGLT2 inhibition in patients with reduced ejection fraction heart failure (HFrEF) DAPA-HF, EMPIRE-HF, EMPEROR-Reduced, there is little convincing left to do about the value of adding SGLT2 inhibitors to the HF armamentarium, as demonstrated by their inclusion in an updated expert decision pathway issued by the American College of Cardiology in early January 2021. But exactly why these drugs provide these demonstrable benefits is still debatable. Jesper Jensen, MD, PhD, of Herlev and Gentofte University Hospital, Herlev, Denmark, and University of Copenhagen, Copenhagen, Denmark, and colleagues drilled down into data from a prespecified substudy of EMPIRE-HF (EMPIRE-HF Renal) to investigate the “effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate (GFR) in patients with hear

EU-funded project creates opportunity for PhD student to join the IPC

Imagen By IPC Thanks to European Union-funding (EU), the International Paralympic Committee (IPC) is one of the beneficiaries from a new initiative that will support 15 PhD positions to study and assess visual abilities. Part of the EU’s research programme Horizon 2020, the OptiVisT project (Optimal support of Visually impaired individuals through inclusive Tests and Tools for testing, training and augmenting Functional Vision) has been granted EUR 4 million over four years. OptiVisT therefore aims to nurture cutting-edge scientists in the EU who will push forward with the scientific and technological breakthroughs needed for new and better solutions for vision care and rehabilitation. Their key mission is to enhance the societal participation of individuals with vision impairment through innovative and inclusive care.

Universitair Medisch Centrum Groningen onderzoekt diagnosestelling dementie

Universitair Medisch Centrum Groningen onderzoekt diagnosestelling dementie
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New president for Sunway

SUNWAY University has appointed Prof Sibrandes Poppema (pic) as its president. It is hoped that Prof Poppema’s appointment will drive its vision to be a world-class university, and to advance its mission to nurture all-round students and become the epicentre of the discovery, advancement, transmission and application of knowledge that meets the needs of society and the global community, the varsity said in a press release on Tuesday. Prof Poppema, a Dutch-Canadian citizen, had served as University of Groningen president from 2008 to 2018. Among his greatest achievements was the merger of its Faculty of Medical Sciences and Academic Hospital, resulting in the University Medical Centre Groningen.

Could Many Covid-19 Deaths Have Been Prevented?

Could Many COVID-19 Deaths Have Been Prevented? Mounting research on vitamin D s effects on COVID-19 has more clinicians and researchers calling for its wider use In recent weeks and months, there have been more studies(1) demonstrating the benefits of vitamin D against COVID-19. More than 200 doctors, scientists, and leading authorities have signed an open letter(2) calling for increased use of vitamin D in the fight against COVID-19. “Research shows low vitamin D levels almost certainly promote COVID-19 infections, hospitalizations, and deaths. Given its safety, we call for immediate widespread increased vitamin D intakes,” the letter states. “Vitamin D modulates thousands of genes and many aspects of immune function, both innate and adaptive,” it continues before listing some of the validated findings on vitamin D.

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