Making This One Change to Your Diet Could Reprogram Your Metabolism, New Study Says
Making This One Change to Your Diet Could Reprogram Your Metabolism, New Study Says
More than two decades of Western diet wisdom have advised us of one rule of thumb: If you want to lose weight, just cut your carbs, and increase protein. However, a revolutionary new study by a team of metabolism and endocrinology researchers has led to the discovery of another aspect of diet that, as the scientists say, had the most potent effect on speeding up metabolism… and, as they suggest, this one change in the foods you eat might even help you live longer.
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BOSTON Obesity increases one s risk for many diseases and often prevents patients from receiving other necessary medical procedures. One of the most effective ways for patients with severe obesity to lose weight is through bariatric surgery, but it s not clear how often this option is raised. In a new study published in
Obesity, investigators from Brigham and Women s Hospital find that eligible patients who discuss bariatric surgery options with their primary care providers or specialists from disciplines ranging from cardiology to urology are more likely to undergo surgery and lose more weight than those who do not have such discussions. But the team also found that these pivotal discussions were exceedingly rare, with fewer than 10 percent of eligible patients having a conversation over the course of a year.
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolic co-factor that is central to energy metabolism. During aging, obesity, and diabetes, NAD+ concentrations in cells decline. NAD+ is synthesized de novo from tryptophan precursors, from nicotinic acid through the Preiss-Handler pathway, or from nicotinamide through the salvage pathway. The rate-limiting enzyme in the salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT), recycles nicotinamide into nicotinamide mononucleotide (NMN), which is converted into NAD+ (see the figure). Restoration of NAD+ concentrations in cells of old or diseased mice through administration of NMN improves health; however, it is unclear whether NMN therapy is practical in humans. On page 1224 of this issue, Yoshino et al. ([ 1 ][1]) show in a randomized, placebo-controlled, double-blind trial that NMN supplementation promotes NAD+ metabolism and improves skeletal muscle insulin sensitivity in postmenopausal prediabetic women who are ov
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