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Duke study reveals mechanisms of increased infectivity, antibody resistance of SARS-CoV-2 variants

Duke study reveals mechanisms of increased infectivity, antibody resistance of SARS-CoV-2 variants
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Newly Described Antibodies with Special Shape Could Unlock Vaccine Strategies for HIV, COVID

Researchers at Duke Human Vaccine Institute (DHVI) have identified a new type of anti-glycan antibody (Ab) that binds to a patch of the chain-like sugars on the outer shell of HIV, effectively neutralizing the virus. The newly identified antibodies, which the team found in both macaques and humans, could lead to development of a novel vaccine strategy that might potentially be used against SARS-CoV-2 and fungal pathogens. “This represents a new form of host defense,” said Barton Haynes, MD, director of the Duke Human Vaccine Institute (DHVI). “These new antibodies have a special shape and could be effective against a variety of pathogens. It’s very exciting.”

Barton haynesPriyamvada acharyaWilton williamsResearchers at duke human vaccine instituteDivision of structural biologyDuke human vaccine instituteViral genetics analysis coreStructural biologyபார்டன் ஹேன்ஸ்பிரியம்வத ஆசார்யாவில்டன் வில்லியம்ஸ்பிரிவு ஆஃப் கட்டமைப்பு உயிரியல்டியூக் மனிதன் தடுப்பூசி நிறுவனம்கட்டமைப்பு உயிரியல்

Newly identified antibody can be targeted by HIV vaccines: Study

Newly identified antibody can be targeted by HIV vaccines: Study ANI | Updated: May 20, 2021 22:39 IST Washington [US], May 20 (ANI): A newly-identified group of antibodies that binds to a coating of sugars on the outer shell of HIV is effective in neutralizing the virus and points to a novel vaccine approach that could also potentially be used against SARS-CoV-2 and fungal pathogens, researchers at the Duke Human Vaccine Institute report. In a study published in the journal Cell, the researchers describe an immune cell found in both monkeys and humans that produces a unique type of anti-glycan antibody. This newly described antibody has the ability to attach to the outer layer of HIV at a patch of glycans the chain-like structures of sugars that are on the surfaces of cells, including the outer shells of viruses.

United statesBarton haynesPriyamvada acharyaWilton williamsDivision of structural biologyDuke human vaccine instituteViral genetics analysis coreStructural biologyஒன்றுபட்டது மாநிலங்களில்பார்டன் ஹேன்ஸ்பிரியம்வத ஆசார்யாவில்டன் வில்லியம்ஸ்பிரிவு ஆஃப் கட்டமைப்பு உயிரியல்டியூக் மனிதன் தடுப்பூசி நிறுவனம்கட்டமைப்பு உயிரியல்

Newly identified antibody can be targeted by HIV vaccines

E-Mail DURHAM, N.C. - A newly identified group of antibodies that binds to a coating of sugars on the outer shell of HIV is effective in neutralizing the virus and points to a novel vaccine approach that could also potentially be used against SARS-CoV-2 and fungal pathogens, researchers at the Duke Human Vaccine Institute report. In a study appearing online May 20 in the journal Cell, the researchers describe an immune cell found in both monkeys and humans that produces a unique type of anti-glycan antibody. This newly described antibody has the ability to attach to the outer layer of HIV at a patch of glycans the chain-like structures of sugars that are on the surfaces of cells, including the outer shells of viruses.

Alberto bartesaghiRichard lagaKartik manneMatthews leeSophie gobeilS munir alamJosephr francicaWilton williamsMegan koppR ryan meyerhoffGarnett kelsoeMarioj borgniaGregoryd sempowskiKevin wieheKatayoun mansouriMattia bonsignori

Oxford University lab researching coronavirus was just targeted in a cyberattack

University of Oxford that is conducting research on the Wuhan coronavirus (COVID-19). Officials from Oxford confirmed that its Division of Structural Biology, known as Strubi, was targeted by a cyber attack sometime in mid-February. The university was quick to point out that, while Strubi was researching the coronavirus, it was distinct from the Jenner Institute, the laboratory that developed the coronavirus vaccine in partnership with pharmaceutical company AstraZeneca. Oxford was alerted to the breach in Strubi when screenshots of the attack were discovered inside the lab’s network. The hackers left these screenshots in one of their “poorly secured servers.”

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