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IMAGE: A preclinical study shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using. view more
Credit: MD Anderson Cancer Center
Abstract #LB008
HOUSTON A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using precision therapy targeting of cell-surface proteins through a Bicycle toxin conjugate (BTC), shows encouraging results for the treatment of osteosarcoma.
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High expression of cell death genes may increase risk of early death from lung cancer
Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report.
Also seemingly paradoxically, patients with high expression of this 21-gene cell death signature the researchers have identified, have indicators that their immune system is attacking the cancer, like higher levels of cytotoxic T cells, which typically kill cancer.
But they also have high levels of molecules that can suppress those T cells, helping transform them into dysfunctional, exhausted T cells, they report in the journal
Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer, are at increased risk of dying early from their disease, researchers report.
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