A new paper in
JNCI Cancer Spectrum, published by Oxford University Press, indicates that several non-genetic factors including greater red meat intake, lower educational attainment, and heavier alcohol use are associated with an increase in colorectal cancer in people under 50.
In the United States, incidence rates of early-onset colorectal cancer have nearly doubled between 1992 and 2013 (from 8.6 to 13.1 per 100,000), with most of this increase due to early-onset cancers of the rectum. Approximately 1 in 10 diagnoses of colorectal cancer in this country occur in people under 50.
Researchers have observed the rise particularly among people born since the 1960s in studies from the United States, Canada, Australia, and Japan. During the same period there have been major changes in diets among younger generations across the developing world. Such changes include decreases in consumption of fruits, non-potato vegetables, and calcium-rich dairy sources. This is coupled with an incre
Cheryl Willman, M.D. has been named Executive Director of Mayo Clinic Cancer Programs and Director of Mayo Clinic Comprehensive Cancer Center. Mayo Clinic is the nation’s top-ranked health care delivery system and hospital. In her new role, Dr..
Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies.
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IMAGE: Darla Kendzor, Ph.D., co-director of the TSET Health Promotion Research Center, was recently awarded a 5-year, $3.1 million grant from the National Cancer Institute to evaluate the effectiveness of an. view more
Credit: OU Health
OKLAHOMA CITY -Darla Kendzor, Ph.D., co-director of the TSET Health Promotion Research Center, was recently awarded a 5-year, $3.1 million grant from the National Cancer Institute to evaluate the effectiveness of an automated, smartphone-based approach to incentivizing smoking cessation among low-income adults in Oklahoma.
Kendzor s past work has uncovered the detrimental impact that financial stress, neighborhood problems, and discrimination can have on smoking cessation. Recently, her work has focused on developing and evaluating practical and effective smoking cessation interventions for vulnerable Oklahomans.
Fasting lowers blood pressure by reshaping the gut microbiota
Nearly half of adults in the United States have hypertension, a condition that raises the risk for heart disease and stroke, which are leading causes of death in the U. S.
At Baylor College of Medicine, Dr. David J. Durgan and his colleagues are dedicated to better understand hypertension, in particular the emerging evidence suggesting that disruption of the gut microbiota, known as gut dysbiosis, can have adverse effects on blood pressure.
The human gastrointestinal tract is home of the gut microbiota, a large community of resident microorganisms known to influence host physiology in health and disease. Image credit: OpenClipart-Vectors.