After Sofia learned she had cancer, her sister stepped in when she needed it most. Author: Liza Lucas Updated: 8:45 AM EST January 28, 2021
ATLANTA From shared laughs to shared adventures, Sofia and Bella Irlando have grown up together. The sisters side by side in the good times, and the hard ones, too.
Such bonds of sisterhood were put to the test after Sofia received the news she had acute myeloid leukemia, a cancer of the blood and bone marrow. It was obviously very scary, it was very stressful, Sofia told 11Alive of her diagnosis.
The news meant not only rounds of chemotherapy for Sofia, but the need for a bone marrow transplant.
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A widely used arthritis drug reduced the rate of acute graft-versus-host disease (GVHD) in both HLA-matched and -mismatched allogeneic stem-cell transplants, a randomized study showed.
The incidence of grade 3/4 acute GVHD after matched transplants decreased from 14.8% with standard prophylaxis to 6.8% with the addition of abatacept (Orencia). In a small group of patients who had 7/8-HLA-mismatched transplants, grade 3/4 acute GVHD at day 100 declined significantly from 30.2% with standard prophylaxis to 2.3% with add-on abatacept (
P 0.001).
Treatment with abatacept was not associated with increased rates of disease relapse or infection, investigators reported in the We found really striking results, particularly with those who were mismatched stem-cell transplants, in preventing acute GVHD, said Benjamin Watkins, MD, of Aflac Cancer and Blood Disorders Center and Emory University in Atlanta. This was a pretty rigorously run trial . and I think with thes