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4D pharma : Annual Report (SEC Filing - 20-F)

Not for trading, but in connection with the registration of American Depositary Shares, pursuant to the requirements of the Securities and Exchange Commission. Securities registered or to be registered pursuant to Section 12(g) of the Act: None None Indicate the number of outstanding shares of each of the issuer s classes of capital or common stock as of the close of the period covered by the annual report: Title of each class Ordinary Shares, nominal value £0.0025 per Share 131,467,935 Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes [ ] No [X]

Saarbrücken based bioinformaticians trace down molecular signals of Parkinson s disease

Credit: Oliver Dietze In their study, which is now published in the journal Nature Aging, they show that the level of non-coding RNAs in the blood of a Parkinson s patient can be used to track the course of the disease. For their study, the team led by bioinformatics professor Andreas Keller and his doctoral student Fabian Kern created and analyzed the molecular profiles of more than 5,000 blood samples from over 1,600 Parkinson s patients. This resulted in around 320 billion data points, which the researchers analyzed for biomarkers of Parkinson s disease using artificial intelligence methods. Our project is among the largest RNA biomarker studies in the world, says Andreas Keller, head of the research group for clinical bioinformatics at Saarland University and spokesperson for the Center for Bioinformatics at the Saarland Informatics Campus.

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