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Paradigm Biopharmaceuticals Ltd granted Australian ethics approval for pivotal Phase 3 clinical trial in participants with knee OA

Little Benefit Seen for Statin Drug in Knee OA

email article The use of atorvastatin (Lipitor) did not reduce cartilage volume loss in patients with knee osteoarthritis (OA) over a period of 2 years, a placebo-controlled study found. Among patients randomized to receive atorvastatin, 40 mg per day, the reduction of tibial cartilage volume was 1.66% per year, while for those given placebo, the reduction was 2.17%, for a between-group difference of 0.50% (95% CI -0.17 to 1.17, P=0.14), reported Flavia M. Cicuttini, PhD, of Monash University in Melbourne, Australia, and colleagues. These findings do not support the use of atorvastatin as a disease-modifying agent in established knee OA, the researchers concluded in their study online in

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