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UK project looks to transform oligonucleotide medicines manufacturing UK catalyst organization, CPI, has announced the launch of a project that aims to revolutionize the manufacture of oligonucleotides, through a collaboration involving, among others, AstraZeneca, Exactmer, and Novartis.
The partners are looking to develop a scalable, sustainable and more cost-effective medicines manufacturing process for oligonucleotides: short strands of synthetic DNA or RNA. They will utilize their combined expertise across scale-up, analytics and process development to achieve those goals.
Oligonucleotides, which are short strands of synthetic DNA or RNA, can be used as medicines by interfering with how genes are expressed. While they have shown success in the treatment of rare diseases, this next-generation therapeutic class is now being explored to treat chronic diseases that affect much larger patient populations, said CPI.