Is old ever too old? Cognitively impaired politicians, judges and physicians Gayatri Devi and Kirk R. Daffner © Getty Images Is old ever too old? Cognitively impaired politicians, judges and physicians
A 60-plus-year-old judge allows her law clerk to don judicial robes while presiding over cases for nearly a year before her dismissal with Alzheimer s disease. An elderly surgeon continues to operate but forgets the location of his office.
As neurologists specializing in cognition, we know that nearly a third of adults 65 years and older suffer from mild cognitive impairment or dementia, climbing to over half by our mid-80s, most often from Alzheimer s disease. Despite these sobering statistics, many of us view aging as optional, deferred with technology. We expect to work into our 80s, replacing our joints and our heart valves when necessary. Unfortunately, our brains can defy our wishes, often shrinking or shriveling despite our best efforts.
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Increased physical activity attenuated
APOE ε4-related vulnerability to early cognitive decline in Parkinson’s disease (PD) patients, a retrospective cohort study found.
“This study provides Class II evidence that increased physical activity was associated with decreased
APOE ε4-related early cognitive decline in PD patients,” wrote Jin-Sun Jun, MD, of Hallym University in Seoul, Korea, and co-authors in
“This protective effect did not appear to be mediated by striatal dopaminergic function,” they added.
Jun and colleagues analyzed data from the Parkinson’s Progression Markers Initiative. All 173 patients (baseline mean age: 63 years) were recently diagnosed with idiopathic PD and had abnormal dopamine transporter (DAT) imaging while untreated. In all, 27% were