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Credit: Johan Wingborg Researchers at the University of Gothenburg, Sweden, have now presented results that may change our basic view of how type 2 diabetes occurs. Their study indicates that free fatty acids (FFAs) in the blood trigger insulin release even at a normal blood-sugar level, without an overt uncompensated insulin resistance in fat cells. What is more, the researchers demonstrate the connection with obesity: the amount of FFAs largely depends on how many extra kilos of adipose tissue a person carries, but also on how the body adapt to the increased adiposity. Worldwide, extensive research is underway to clarify exactly what happens in the body as type 2 diabetes progresses, and why obesity is such a huge risk factor for the disease. For almost 50 years, diabetes researchers have been discussing their version of the chicken-or-egg question: Which comes first insulin resistance or elevated insulin levels? The dominant hypothesis has long been that the pancreas steps up

Uppsala lanVastra gotalands lanEmanuel frykAnders janssonUppsala universitySahlgrenska academyUniversity of gothenburgTranslational medical researchMedicine healthMetabolism metabolic diseasesஆண்டர்ஸ் ஜான்சன்பல்கலைக்கழகம் ஆஃப் கோடெந்ப்ர்க்மொழிபெயர்ப்பு மருத்துவ ஆராய்ச்சிமருந்து ஆரோக்கியம்வளர்சிதை மாற்றம் வளர்சிதை மாற்ற நோய்கள்நீரிழிவு நோய்