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Reducing COVID-19 burden with monoclonal antibodies and vaccination
Researchers in the United States, the UK and France have shown that using antiviral monoclonal antibodies in combination with vaccination can be expected to suppress the transmission of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) and reduce the burden of coronavirus disease 2019 (COVID-19) more than vaccination alone.
The team’s modeling simulations suggested that the near-term use of monoclonal antibodies (mAbs) for early treatment and post-exposure prophylaxis (PEP) in combination with vaccination would substantially reduce SARS CoV-2 transmission and COVID-19 mortality.
Mohamed Kamal from Regeneron Pharmaceuticals in Tarrytown, New York and colleagues say that allocating mAbs solely as PEP or targeting those aged 65 years and older provided the most significant incremental benefits relative to vaccination alone.
United-statesNew-yorkUnited-kingdomFranceMohamed-kamalSally-robertsonRegeneron-pharmaceuticals-in-tarrytownRegeneron-pharmaceuticalsMonoclonal-antibody-treatmentVaccines-combinedImage-creditஒன்றுபட்டது-மாநிலங்களில்Liam Campling and Alejandro Colás
Beginning in the late 1860s, the decade that it took to construct the Suez Canal, photographs depicting its feats of engineering circulated across the world. Sold to travelers as souvenirs, featured in
Le Monde, and later exhibited at the 1889 Paris world fair, they enshrined on paper the industrial monumentality of the dredgers that excavated earth into sea.
The Ever Given provided a rare glimpse into global markets, whose workings are typically invisible—dissolved in the abstract, numerical, quasi-magical relations of capital flows.
As publicized images of the machinic wonders of modernity, they also served as promissory notes, enticing investors to purchase shares in the joint-stock Suez Canal Company. The photographs telegraphed seductive promises of financial gain, pictorializing the genius of European engineering that could dig a manmade channel across the African continent. Running through the pictures, historian Mohamed Gamal-Eldin discovered, was a striking pattern. For the technological sublime to work its wonder on the awed spectator, the photos had to be evacuated of the laboring subjects who made the feat possible: the many tens of thousands of dispossessed fellahin—peasants—who dug the monumental canal by hand.
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