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Common brain disorder more likely in kids with big heads

A common brain disorder called Chiari 1 malformation can result from variations in two genes involved in brain development, research finds. The study also reveals that children with unusually large heads are four times more likely to be diagnosed with Chiari 1 malformation than their peers with normal head circumference. The condition occurs when the lowest parts of the brain are found below the base of the skull. About one in 100 children has Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem. But in about one in 10 of those children, the condition causes headaches, neck pain, hearing, vision and balance disturbances, or other neurological symptoms.

United statesBetsy reevesGabriel hallerCenters for diseaseDevelopmental disabilities research center at washington universityNational centerWashington university institute of clinicalWashington university school of medicineReeves syringomyelia research consortiumTranslational sciencesChildren discovery institute of stLejeune foundationWashington universitySwiss national science foundationAmerican journalHuman genetics

Aggressive RBC Transfusions No Help in Extremely Small Babies

email article Extremely small newborns tolerated a restrictive red blood cell transfusion strategy for anemia in the multicenter TOP trial. Around 2 years of age, infants had similar rates of either death or survival but with neurodevelopmental impairment (i.e., cognitive delay, cerebral palsy, hearing, or vision loss) whether they had been randomized to higher or lower hemoglobin thresholds for transfusion in the neonatal intensive care unit (NICU) shortly after birth (50.1% vs 49.8%, adjusted RR 1.00, 95% CI 0.92-1.10). The individual components of death (16.2% vs 15.0%) and neurodevelopmental impairment (39.6% vs 40.3%) were no different between the higher and lower hemoglobin strategies, respectively, according to a group led by Haresh Kirpalani, MD, MSc, of Children s Hospital of Philadelphia.

Stanford universityUnited statesNicole louHaresh kirpalaniHuman developmentStanford university school of medicineNew england journalLance princeStanford university schoolLucile packard childrenHospital stanfordMedpage todayNeonatal research networkEunice kennedy shriver national instituteChild healthEngland journal

NIH funds eight studies to uncover risk factors for COVID-19-related inflammatory syndrome in children

Share this article Share this article BETHESDA, Maryland., Dec. 28, 2020 /PRNewswire-HISPANIC PR WIRE/ The National Institutes of Health has awarded eight research grants to develop approaches for identifying children at high risk for Multisystem Inflammatory Syndrome in Children (MIS-C), a rare and severe after-effect of COVID-19 or exposure to the virus that causes it. Up to $20 million will be provided for the projects over four years, pending the availability of funds. These awards underscore NIH s commitment to identifying children at risk for MIS-C, which will inform development of interventions to improve their health outcomes, said Diana Bianchi, M.D., director of NIH s

United statesMount pleasantNew brunswickNew jerseySan diegoBaylor college of medicineSan franciscoJohns hopkins universityNational institutes of healthCedric manlhiotDiana bianchiAudreyr odom johnUsha sethuramanLawrence kleinmanAnanthv annapragadaJuanc salazar

Women in 3rd trimester unlikely to pass Covid infection to newborns

Women in 3rd trimester unlikely to pass Covid infection to newborns
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United statesDiana bianchiHuman developmentUs national institutes of healthEunice kennedy shriver national instituteChild healthஒன்றுபட்டது மாநிலங்களில்டயானா பியாஞ்சிமனிதன் வளர்ச்சிஎங்களுக்கு தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம்யூனிஸ் கெந்நெடீ ஶ்ரைவர் தேசிய நிறுவனம்குழந்தை ஆரோக்கியம்

Pregnant women in 3rd trimester unlikely to pass Covid infection to newborns

Pregnant women in 3rd trimester unlikely to pass Covid infection to newborns
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