Mice study points to a promising treatment for relieving colitis pain without side effects
A targeted opioid that only treats diseased tissues and spares healthy tissues relieves pain from inflammatory bowel disease without causing side effects, according to new research published in the journal
Gut.
The study, led by researchers at New York University College of Dentistry and Queen s University in Ontario, was conducted in mice with colitis, an inflammatory bowel disease marked by inflammation of the large intestine.
Opioids, which are used to treat chronic pain in people with inflammatory bowel disease, relieve pain by targeting opioid receptors, including the mu opioid receptor. When opioids activate the mu opioid receptor in healthy tissues, however, they can cause severe and life-threatening side effects, including difficulty breathing, constipation, sedation, and addiction.
Children have fared better than adults in the coronavirus pandemic, a fact that makes the development of vaccines for them a unique effort in the annals of medical science.
The first children have now received doses in Moderna s trial to test its vaccine in kids ages six months to under 12. It gave no timeline, but it will likely take months for the firm to have trial results.
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