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Queen Mary University of London In those who have not previously been infected and have so far only received one dose of vaccine the immune response to variants of concern may be insufficient. The findings, published today in the journal Science and led by researchers at Queen Mary University of London, Imperial College London and University College London, looked at immune responses in UK healthcare workers at Barts and Royal Free hospitals following their first dose of the Pfizer/BioNTech vaccine. They found that people who had previously had mild or asymptomatic infection had significantly enhanced protection against the Kent and South Africa variants, after a single dose of the mRNA vaccine. In those without prior COVID-19, the immune response was less strong after a first dose, potentially leaving them at risk from variants.

South africaUnited kingdomCity ofJoseph gibbonsRosemary boytonCorinna padeUniversity college londonUniversity of nottinghamMedicine at imperial college londonImperial college londonQueen mary university of londonPublic health englandBarts healthBarts charityResearch councilResearch scientist at queen mary blizard institute