Do you work for one of the largest employers in the Rochester area? Everyone knows that Mayo is the big dog in Rochester, Minnesota. Did you know, with its 35,000+ employees, it's actually the largest employer in the entire state? There's a good chance that you or someone close to you works for the clinic. Below you'll see the top ten employers in our area according to RAEDI (Rochester Area Economic Development). There's quite the drop from #1 to #2.