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A team of Roswell Park Comprehensive Cancer Center researchers has identified a new biomarker that could predict response to immune checkpoint inhibitors (ICI) shortly after patients with non-small cell lung cancer (NSCLC) initiate therapy.
Roswell Park Researchers Identify New Biomarker of Response to Checkpoint Inhibitors
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A team of Roswell Park Comprehensive Cancer Center researchers has identified a new biomarker that could predict response to immune checkpoint inhibitors (ICI) shortly after patients with non-small cell lung cancer (NSCLC) initiate therapy. This discovery, published today in the journal Nature Communications, is not only an important step forward in lung cancer treatment, but also has implications for other malignancies, according to lead author Fumito Ito, MD, PhD, FACS.
BUFFALO, N.Y. (PRWEB) March 03, 2021
Discovery in lung cancer could help determine which patients will benefit most from immunotherapy
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A study led by researchers at Baylor College of Medicine reveals a novel role of the steroid receptor coactivator 3 (SRC-3/NCOA3), a protein crucial for steroid hormone function and a prognostic marker for aggressive human breast and other cancers.
The team discovered that SRC-3 also regulates human immune T regulatory cells (Tregs), which contribute to the regulation of the body s immunological activity by suppressing the function of other immune cells, including those involved in fighting cancer. The study, which appears in the journal
Scientific Reports, shows that Tregs whose SRC-3 function was eliminated failed to suppress the activity of other immune cells in the lab. The authors anticipate that their findings may help in the fight against cancer in the future by leading to new approaches to inhibit Tregs activity which consequently would release immune attack in tumors.
Scientific Innovations Coming Out of Cuba
Cuba’s remarkable achievement is now leading many to wonder what other medical advances it could share with the world. Candace Johnson is president and CEO of Roswell Park Comprehensive Cancer Center in Buffalo, New York. She has worked closely with Cuban scientists to bring their lung cancer vaccine to the U.S. for trials. Read more