Abstract
Cognitive dysfunction is a core feature of many brain disorders, including schizophrenia (SZ), and has been linked to aberrant brain activations. However, it is unclear how these activation abnormalities emerge. We propose that aberrant flow of brain activity across functional connectivity (FC) pathways leads to altered activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping, an approach that models the movement of task-related activity between brain regions as a function of FC. Using functional magnetic resonance imaging data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in patients. Our results suggest that dysfunctional t
Santa Clarita Woman Found Dead At Newhall Metrolink Station Identified
hometownstation.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from hometownstation.com Daily Mail and Mail on Sunday newspapers.
Dead Body Found Near Vehicle At Newhall Metrolink Station
hometownstation.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from hometownstation.com Daily Mail and Mail on Sunday newspapers.
Congressman Garcia Discusses PTSD, Mental Health In The Military
In recognition of June as National Post-Traumatic Stress Disorder (PTSD) Awareness Month, former U.S. Navy Pilot Congressman Mike Garcia, R-Santa Clarita, sat down with KHTS to discuss public awareness about issues related to PTSD.
PTSD is a psychiatric condition that can occur when someone has seen or experienced a traumatic event and is often associated with military service, although it can affect anyone and can present itself in a variety of symptoms.
“It’s a spectrum, there are some people who just have a hard time dealing with say, loud noises, there are some people who have a hard time dealing with people and interacting socially, and then there are others that when it gets really bad they truly want to end their life,” Garcia said. “This is why we have to treat every case as if it was a more serious case until we know it’s not.”