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 E-Mail IMAGE: Researchers from Aarhus University have discovered that ITIH4 inhibits proteases in the innate immune system via an unknown mechanism. Figure: Rasmus Kjeldsen Jensen. view more  Credit: Rasmus Kjeldsen Jensen, Aarhus University Although the protein ITIH4 is found in large amounts in the blood, its function has so far been unknown. By combining many different techniques, researchers from Aarhus University have discovered that ITIH4 inhibits proteases in the innate immune system via an unknown mechanism. The research results have just been published in the prestigious scientific journal Science Advances. Proteases are enzymes that cleave other proteins. Most often, proteases occur in cascade networks, where a particular event triggers a chain reaction in which several proteases cleave and thereby activate each other. Most well known is probably the coagulation cascade, which causes clotting of our blood when a vessel is punctured.

Winston churchillSteffen thielLisbeth jensenJanj enghildRasmusk jensenRasmus kjeldsen jensenRasmus pihlAnnetteg hansenGregersr andersenDepartment of molecular biologyDepartment of biomedicine at aarhus universityDepartment of biomedicineNovo nordisk foundationAarhus universityProfessor steffen thielMolecular biology